For Microsoft 365 plans, Internet access is also needed to manage your subscription account, for example to install Office on other PCs or to change billing options. Internet access is required to install and activate all the latest releases of Office suites and all Microsoft 365 subscription plans. How do I know my PC or Mac can run Office? One-time purchases don’t have an upgrade option, which means if you plan to upgrade to the next major release, you'll have to buy it at full price. Office 2021 is a one-time purchase that comes with classic apps like Word, Excel, and PowerPoint for PC or Mac, and does not include any of the services that come with a Microsoft 365 subscription. With a subscription, you get the latest versions of the apps and automatically receive updates when they happen. Microsoft 365 also comes with services like 1 TB of OneDrive storage, 60 Skype minutes per month, and Microsoft chat and phone support. The apps can be installed on multiple devices, including PCs, Macs, iPads, iPhones, Android tablets, and Android phones. Microsoft 365 is a subscription that comes with premium apps like Word, Excel, PowerPoint, OneNote, Outlook, Publisher, and Access (Publisher and Access available on PC only). Which version of Microsoft 365 should I choose? Learn more about the differences between Microsoft 365 and Office 2021 in Office Support, or use the comparison chart to help you pick the right Office version for your needs. Office 2021 is a one-time purchase that comes with classic apps like Word, Excel, and PowerPoint for PC or Mac, and does not include any of the services that come with a Microsoft 365 subscription. The apps can be installed on multiple devices, including PCs, Macs, iPads, iPhones, Android tablets, and Android phones. Microsoft 365 also comes with services like 1 TB of OneDrive storage, 60 Skype minutes per month, and Microsoft chat and phone support.
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Instagram is one of the most effective social media platforms where you can promote your brand and see quick and long-lasting results. Do More With Simplified’s Instagram Post Scheduler HealthcareĪs you may have noticed, industries are most active during weekdays, so you may try to experiment with posting on Instagram throughout the week. If you want to create posts related to tech – try out these days and times. However, you may try experimenting with different times that will bring positive results.įor instance, the technology people get activated on Instagram on Wednesday, Friday, and Saturday morning. TechnologyĪs you already know, there is no rule of thumb on when to post on Instagram. If you want to reach people interested in retail, consider posting on Wednesday afternoons and late mornings on Friday. Instagram has become incredibly important for the retail industry because many people use it as a shopping page. Therefore, your best chances of engagement are during working hours, 8 AM – 5 PM on Wednesday, Thursday, and Friday. Social media is super important for the entertainment district, and it’s essential to know when to post.įor example, it would be a good time to post on Friday mornings at 9 AM because people usually start to plan their weekends and look for ideas. You should still consider the industry you are in and the type of audience you have. In addition, you’ll get more likes, comments, and saves after posting! Best Times To Post On Instagram By IndustryĪs the name states, the timeline guide provided in this article is only a guide. Related: Instagram Reels: What They Are And How You Can Optimize Them For Highest Engagementīecause more followers will actively see your posts, you’ll notice a significant increase in your engagement rate. It will show them that you’re interested in engaging with them and appreciate their likes, comments, and reposts. Pushing content on Instagram during peak times will help you regularly connect with your followers. Moreover, this increases the chance for new users to discover your account and posts, allowing you to reach more people on the platform. If you post whenever your followers are active, your new content will likely be among the first posts they see. Here are some of the most notable changes you will notice: Wider Reach The bottom line is that posting when your followers are most active will significantly impact your digital marketing campaign. Related: Here’s How to Add Music to Instagram Posts to Make Them Stand Out Why Follow The Best Time To Post On Instagram? However, it’s also crucial to note that the proportion of engagement may depend on the specific day of the week you post: This is because users are the most active during this timeframe, ensuring that more people will see and hopefully engage with your content. On average, the best time to post on Instagram is between 10 AM and 3 PM. And while there’s no “perfect” time to post, pushing content during the “best” time is still crucial. With the redesigned cutting chamber, you are ready with great capacity and better crop flow. Put these M-Series Rotary Cutters to work reclaiming overgrown pastures, mowing rights-of-way, and chopping row-crop residue. Choices include 540 PTO rpm or 1000 PTO rpm, laminated or severe-duty ag tires, and round stump jumper or bar-type blade holder. Get a lot done on the job and then fold up the wings for easy transport. M-Series Flex-Wing Cutters are suited for larger property owners and ag producers.Ī flex-wing rotary cutter is the best way to go when dealing with large areas and uneven terrain. The E Series shares many design features of the M and R Series, such as the easy-clean deck, round blade pans, and a cast self-leveling clevis hitch. 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John Deere flex-wing rotary cutters are available in three duty-level categories and four width sizes.Į-Series Flex-Wing Cutters are designed for your utility tractor to increase efficiency in each pass. Choose the right features to satisfy specific needs – check out the value and benefits for each option to determine which one is the best fit for the work. Tractor compatibility – if there is a tractor the operator will be using, look for the tractor compatibility sheet to identify appropriate options.The amount of time and frequency it will be used – for longer hours and more frequency, choose a heavier duty machine.The size of the area to mow versus the size of the machine – the bigger the area to mow, the bigger the mower needs to be to perform efficiently during mowing hours.Control undergrowth and grass in orchards, vineyards, and groves.This is essential in no-till and minimum-till fields. Knocking down stalks such as cotton, corn, or milo speeds up decomposition.Cutting grass waterways encourages root development and helps prevent erosion.It is the most cost-efficient way to cut roadsides, parks, cemeteries, airport fields, hydro, gas, and telephone easements, and all other types of open properties.Routine cutting keeps weeds from reseeding.Cutting grass and stalks helps control insects.Clipping pastures encourages grass growth, optimizing on valuable pasture acreage.Here are situations when a rotary cutter provides value: John Deere rotary cutters continue to advance in value with larger, more powerful gearboxes, and updated constant-velocity (CV) drivelines. To help promote safe operation, John Deere rotary cutters are equipped with front and rear safety-chain shields and lighting kits to comply with U.S. The cutting chamber design allows the material to flow through the area and be discharged evenly throughout the width of the machine. Valuable features are included such as a dome-shaped smooth deck, which prevent water and debris from accumulating on the top of the machine and makes it easy to clean up.īuilt with a superior structural design that will satisfy different applications and segment desires, the single deck on the flex-wing cutters adds volume on the cutting chamber, allowing the machine to process more material and translating into an improvement in cut quality. John Deere flex-wing rotary cutters lead the way with innovative design, superior durability, and proven performance. NOTE: Only for E, M, and R flex-wing models. Mass planted Senecio serpens Landscaping IdeasĬonsider planting on a screed or gravelled covered area.
Tribbles 2 pseudokinase confers enzalutamide resistance in prostate cancer by promoting lineage plasticity. Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy. Isn't Androgen Deprivation Enough? Optimal Treatment for Newly Diagnosed Metastatic Prostate Cancer. Identification of alternative protein targets of glutamate-ureido-lysine associated with PSMA tracer uptake in prostate cancer cells. What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021. 2022 07 257(3):274-284.ĭetecting Neuroendocrine Prostate Cancer Through Tissue-Informed Cell-Free DNA Methylation Analysis. 2022 06 16(12):2384-2395.Ĭomparative genomics of primary prostate cancer and paired metastases: insights from 12 molecular case studies. The genomic landscape of metastatic clear cell renal cell carcinoma after systemic therapy. 2022 07 82(1):115-141.Ĭorrigendum to "What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021". Management of Patients with Advanced Prostate Cancer: Report from the Advanced Prostate Cancer Consensus Conference 2021. 2022 May 20 Suppl 9(5):1-20.Įditorial: Metastatic prostate cancer: a wealth of data to put into practice. 2022 05 20 Suppl 9(5):2-8.įactors that guide selection among androgen receptor inhibitors in patients with nonmetastatic castration-resistant prostate cancer. Recent clinical trial data of androgen receptor inhibitors in patients with nonmetastatic castration-resistant prostate cancer. 2022 05 27 376(6596):eabe1505.Īllele-informed copy number evaluation of plasma DNA samples from metastatic prostate cancer patients: the PCF_SELECT consortium assay. 2022 07 01 28(13):2771-2778.Ĭhromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets. Predictive Biomarkers of Overall Survival in Patients with Metastatic Renal Cell Carcinoma Treated with IFNa ± Bevacizumab: Results from CALGB 90206 (Alliance). 2023 01 9(1):110-113.įuture directions for precision oncology in prostate cancer. Moving Precision Oncology for Advanced Prostate Cancer from Theory to Practice. 2022 11 01 132(21).ĬHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2. 2022 11 6:e2200382.Ī clinical-grade liquid biomarker detects neuroendocrine differentiation in prostate cancer. Response to MEK Inhibitor Therapy in MAP2K1 (MEK1) K57N Non-Small-Cell Lung Cancer and Genomic Landscape of MAP2K1 Mutations in Non-Small-Cell Lung Cancer. 2022 11 07 12(1):18879.ĭL元 as an Emerging Target for the Treatment of Neuroendocrine Neoplasms. The NOGO receptor NgR2, a novel aVß3 integrin effector, induces neuroendocrine differentiation in prostate cancer. Part I: Intermediate-/High-risk and Locally Advanced Disease, Biochemical Relapse, and Side Effects of Hormonal Treatment: Report of the Advanced Prostate Cancer Consensus Conference 2022. Management of Patients with Advanced Prostate Cancer. Impact of early detection on cancer curability: A modified Delphi panel study. In addition, within Dana Farber and through national and international collaborations, we work with a multidisciplinary team of scientists and clinicians towards the development of next generation molecular platforms and biomarkers for the clinical application of precision medicine across tumor types. Our mission is to make discoveries that improve the way we manage and treat patients with advanced prostate cancer. We are developing tissue and circulating biomarkers and novel therapeutic strategies for clinical translation. We have used genomics and epigenomics to elucidate the molecular mechanisms driving evolution towards an AR-low state. We have focused on understanding mechanisms underlying an emerging subclass of androgen-indifferent prostate cancers that develop neuroendocrine features as an adaptive response mechanism upon selective therapeutic pressure of the androgen receptor (AR). My lab is focused on understanding mechanisms of treatment resistance in advanced prostate cancer through the integration of clinical and molecular features of patients combined with preclinical modeling. 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The square Home button at the bottom of the box functions exactly like the physical home button - you can use it to single tap, double tap, or long press the home button even if there is a hardware problem. How to change button shortcuts on Galaxy Watch 4 Swipe down to open Quick Settings. Tap this circle to expand it to a big box on screen. On the next screen, toggle AssistiveTouch to the green On position.Ī white circle with a grey box will appear on screen. Scroll down to the section labeled INTERACTION and tap on AssistiveTouch. If you're facing the same problem, then you should enable the software home button option on your iOS device, and this is how you do it: How to Add Touchscreen Home Button on iPhone, iPad This can really make using the device frustrating, particularly if you're using an older device that doesn't support gestures. Home Button application can replace a failed and broken home button for those people who has trouble using button. 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It all starts with a strong log line, the setup of a powerful dilemma and a clear. Please email us at to arrange for services. I believe that this method will help you write a stronger TV pilot script. Accommodations and services are designed to meet the needs of each participant. Sundance Collab provides accommodations and support services to participants with disabilities. Applications for this course are considered as they are received and applicants are accepted on a rolling basis until the course is full or the deadline has passed, whichever comes first. conclude with a one-on-one mentoring session with your advisor.Ĭourse enrollment is approximately 36 participants per session, with a participant to advisor ratio of 9-to-1.connect you with other creators via a discussion board where you can talk through core concepts and share your work.offer opportunities for designated homework to be reviewed by a Sundance Advisor.provide tools and techniques to apply to your project.How to give notes to your peers and process notes from your peers and advisors.How to rewrite, re-break, and adjust your script.How to manage your pace and story engine for your pilot.How to effectively use dialogue to bring your characters to life and move the plot forward.How to set up character conflicts that will keep your viewers watching.How to sharpen your main and secondary characters.A review of the foundations of serialized and episodic storytelling, including different structures and A/B/C storylines.We recommend that you complete Sundance Collab’s TV Writing: Core Elements prior to taking this course. a completed beat sheet, outline or draft of your original pilot.Read some pilots for The Office, Breaking Bad, The Sopranos, and Game of Thrones to see how those successful shows got started. The logline and show bible simply suggest an idea the pilot turns it into a reality. The course concludes with a one-on-one mentoring session with your advisor focused on your pilot and questions you may have about the field. Writing a pilot, youve successfully taken this idea and put it into a viable form. In this course you will move from outline to completing a draft of your original pilot with experienced TV writers as your guides. Now, it’s time to start writing that script that grabs your reader’s attention - whether it’s an agent, an executive, or a showrunner. You’ve got a great idea for a TV series and you have fleshed out an outline for your pilot. This is why each run of the Mariveles is distinct-the precise colors vary depending on what’s available. Like many of the company’s bags (indicated by the Del Día name), the Mariveles duffle is made from discarded material otherwise destined for the cutting-room floor, left over from other companies’ larger production runs. It’s a listed B Corp, and it takes pains to be as sustainable in its bags’ construction as possible, with a particular focus on labor practices. We also continue to be impressed by Cotopaxi’s overall transparency and social mission. Adventure Rolling Duffle Bag, Extra-Large. In contrast, however, it’s made of repurposed ripstop nylon that’s of a higher quality than the Herschel’s polyester, and it’s available for a lower price (though it lacks the Herschel bag’s included shoulder strap). Like the Herschel bag, the Cotopaxi Mariveles 32L Duffel Bag Del Día has the classic shape and feel of a barrel duffle. Why it’s great: This kind of barrel-shaped 30-liter bag is something of a platonic ideal among duffle designs. Product Details Adventures don’t always go according to plan but this road-tested rolling duffle comes through every time, thanks to rugged, water-resistant fabrics and reliable zippers. Patagonia has a highly regarded replacement and repair guarantee that we’ve tested many times without complaint. The Black Hole folds down into its own stuff sack, which turns into a storage pocket when you unfold the duffle. (We originally tested a now-discontinued 120-liter version.) For all practical purposes, the bags are identical except for their increasing size, though the smaller sizes come in a wider range of colors-up to 13-than do the larger sizes. The Black Hole is available in three other sizes, too: 40 liters, 55 liters, and 100 liters. Category Women Bags Travel Bags Color Purple Shipping/Discount 7. Only used 1 or 2 times, so excellent/like new condition. You can carry the Black Hole at your side using the two handles or over your shoulder using the strap, or you can wear it as a backpack with its two padded straps. Bean 48 120 Size OS This item is sold Like and save for later Beautiful, durable LL Bean rolling duffel bag in purple color. 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